Last Updated: June 2023
In general, tenofovir disoproxil and emtricitabine with both dolutegravir and raltegravir are well tolerated when taken as PEP.17,24,25,27,28,56,65 If a patient reports intolerable or serious side-effects from a previous PEP course: an alternative PEP regimen should ideally be prescribed in emergency (out of hours) situations (unless previously reported side-effects were serious) the available PEP regimen …
A comprehensive medication history (including over-the-counter medications, vitamin and mineral supplements and recreational drugs) is essential before initiating PEP. Potential drug-drug interactions can be checked using the Liverpool HIV Drug Interactions checker website. Tenofovir disoproxil and emtricitabine no significant drug-drug interactions caution and consideration of more frequent renal monitoring if co-administered with other potentially nephrotoxic …
Key recommendations After potential exposure to HIV, people should have baseline and follow-up testing for HIV, STIs and other BBVs as outlined in Table 4. Where HIV testing results are indeterminate, repeat HIV testing should occur one to two weeks later. When baseline HIV Ag/Ab result is positive and the HIV WB result is delayed, …
The risk of HIV transmission through a single exposure is determined by: The nature of the exposure with its estimated risk per exposure (Table 1) If the source is known to be HIV positive and viraemic (Table 2) The risk that the source is HIV positive and viraemic if their status is unknown (Table 2 …
Key recommendations Provision of PEP should not be delayed while establishing the source HIV status. Informed consent should be sought from the source when performing an HIV test. It is important to note the sensitivity of gathering information on an individual’s HIV status and ensure the source individual’s privacy and confidentiality. If the source is …
What is the HIV status of the source individual? Read More »
Advice should be given for the following blood and body fluid exposures: Vaginal: do not douche Rectal: do not douche Oral cavity: spit out blood and body fluids and rinse mouth well with water Eyes: irrigate well with clean water or normal saline Other mucous membranes: irrigate well with water Intact skin exposures: wash with …
Immediate management of a person with known or suspected exposure to HIV Read More »
The following should be discussed and documented in the patient’s medical record: Information about the source, where available (as outlined in section: Assessment of the risk of HIV transmission) Information about the exposure Date and time of exposure Type of exposure, including sites(s) involved, blood or body fluids involved, trauma, first aid measures applied and …
These guidelines are pending endorsement by the Blood Borne Viruses and Sexually Transmitted Infections Standing Committee (BBVSS).
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