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Post-Exposure Prophylaxis after non-occupational and occupational exposure to HIV 

Australian National Guidelines (Third Edition)

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Last Updated: June 2023

Specific Clinical Situations for PEP

People who re-present for PEP after completion of a PEP course

Disproportionately higher rates of HIV acquisition occur among people who have previously used PEP.13-15

It is recommended that clinicians follow this guidance:

  • patients who present for repeat PEP should be treated in a non-judgemental manner
  • each presentation should be assessed as per the risk assessment process described in this guideline (see section: Assessment of the risk of HIV transmission)
  • unless the exposure is isolated (e.g. an isolated condom failure, high-risk sexual assault), transitioning immediately onto PrEP after the PEP course should be discussed and recommended for repeat PEP presenters in most circumstances
  • consider referral to a counsellor or psychologist for supported decision-making.

Endorsed By

These guidelines are pending endorsement by the Blood Borne Viruses and Sexually Transmitted Infections Standing Committee (BBVSS).

Funded By: The Australian Government Department of Health
Disclaimer: Whilst the Australian Department of Health provides financial assistance to ASHM Health, the material contained in this resource produced by us should not be taken to represent the views of the Australian Department of Health.

The content of this resource is the sole responsibility of ASHM Health.

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