Disproportionately higher rates of HIV acquisition occur among people who have previously used PEP.13-15
It is recommended that clinicians follow this guidance:
- patients who present for repeat PEP should be treated in a non-judgemental manner
- each presentation should be assessed as per the risk assessment process described in this guideline (see section: Assessment of the risk of HIV transmission)
- unless the exposure is isolated (e.g. an isolated condom failure, high-risk sexual assault), transitioning immediately onto PrEP after the PEP course should be discussed and recommended for repeat PEP presenters in most circumstances
- consider referral to a counsellor or psychologist for supported decision-making.